APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review

Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the signifi...

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Veröffentlicht in:	Oncotarget 2017-07, Vol.8 (28), p.46468-46479
Hauptverfasser:	Liang, Tie-Jun, Wang, Hong-Xu, Zheng, Yan-Yan, Cao, Ying-Qing, Wu, Xiaoyu, Zhou, Xin, Dong, Shu-Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli Protein - genetics Biomarkers, Tumor Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics DNA Methylation Early Detection of Cancer Epigenesis, Genetic Female Genetic Association Studies Genetic Predisposition to Disease Humans Male Meta-Analysis Neoplasm Grading Neoplasm Staging Odds Ratio Promoter Regions, Genetic Publication Bias Sex Factors
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Zusammenfassung:	Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the significance of APC methylation in CRC. The study included a total of 24 articles and 2025 CRC patients. The frequency of APC promoter hypermethylation was significantly higher in colorectal adenoma than in normal colorectal tissue, OR was 5.76, 95% CI, 2.45-13.56; p
ISSN:	1949-2553 1949-2553
DOI:	10.18632/oncotarget.17576