Dopamine Protects Cerebral Autoregulation and Prevents Hippocampal Necrosis after Traumatic Brain Injury via Block of ERK MAPK in Juvenile Pigs

Highlights • Traumatic brain injury (TBI) impairs cerebral autoregulation. • CPP is normalized after TBI by use of vasoactive agents to increase MAP. • Effects of norepinephrine, epinephrine, phenylephrine are sex and age dependent. • Dopamine improves outcome after TBI independent of age and sex. •...

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Veröffentlicht in:	Brain research 2017-09, Vol.1670, p.118-124
Hauptverfasser:	Curvello, Victor, Hekierski, Hugh, Pastor, Philip, Vavilala, Monica S, Armstead, William M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Injuries - metabolism Brain Injuries, Traumatic - drug therapy Cerebrovascular Circulation - physiology Dopamine - metabolism Dopamine - pharmacology Epinephrine - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Female Hippocampus - drug effects Hippocampus - metabolism Homeostasis - drug effects Homeostasis - physiology Male MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Necrosis - metabolism Necrosis - prevention & control Neurology Norepinephrine - pharmacology Phenylephrine - pharmacology Swine - metabolism Swine - physiology Up-Regulation - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects
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Zusammenfassung:	Highlights • Traumatic brain injury (TBI) impairs cerebral autoregulation. • CPP is normalized after TBI by use of vasoactive agents to increase MAP. • Effects of norepinephrine, epinephrine, phenylephrine are sex and age dependent. • Dopamine improves outcome after TBI independent of age and sex. • Dopamine should be considered the drug of choice in treatment of pediatric TBI.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.06.010