Circulating inflammatory biomarkers in relation to brain structural measurements in a non-demented elderly population

Highlights • Cross-sectional and longitudinal associations between inflammatory biomarkers brain structural measures were examined among elderly individuals without dementia. • Higher interleukin-6 level was associated with smaller brain volume in the cross-sectional analysis. • Higher alpha 1-antic...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-10, Vol.65, p.150-160
Hauptverfasser:	Gu, Yian, Vorburger, Robert, Scarmeas, Nikolaos, Luchsinger, José A, Manly, Jennifer J, Schupf, Nicole, Mayeux, Richard, Brickman, Adam M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Allergy and Immunology Alpha 1-antichymotrypsin alpha 1-Antichymotrypsin - analysis alpha 1-Antichymotrypsin - metabolism Atrophy - pathology Biomarkers - blood Biomarkers - metabolism Brain - anatomy & histology Brain - immunology Brain - pathology Brain atrophy Brain morphometry C-reactive protein C-Reactive Protein - analysis C-Reactive Protein - metabolism Cohort Studies Cortical thickness Diffusion Tensor Imaging - methods Female Gray Matter - pathology Healthy Volunteers Humans Inflammation - blood Interleukin-6 Interleukin-6 - analysis Interleukin-6 - metabolism Longitudinal Studies Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Neuroepidemiology Psychiatry White Matter - pathology
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Zusammenfassung:	Highlights • Cross-sectional and longitudinal associations between inflammatory biomarkers brain structural measures were examined among elderly individuals without dementia. • Higher interleukin-6 level was associated with smaller brain volume in the cross-sectional analysis. • Higher alpha 1-antichymotrypsin level tended to be associated with thinner cortical thickness in the cross-sectional analysis. • The results suggest peripheral inflammatory processes may be involved in the brain atrophy in the elderly.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2017.04.022