Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)–H Bonds
We herein report the palladium(II)-catalyzed bromination and iodination of a variety of α-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and...
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| Veröffentlicht in: | Journal of the American Chemical Society 2017-04, Vol.139 (16), p.5724-5727 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | We herein report the palladium(II)-catalyzed bromination and iodination of a variety of α-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp3)–H bromination, enabled by quinoline ligands. |
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| ISSN: | 0002-7863 1520-5126 |
| DOI: | 10.1021/jacs.7b02196 |