(2 + 1)D‐CAIPIRINHA accelerated MR spectroscopic imaging of the brain at 7T

Purpose To compare a new parallel imaging (PI) method for multislice proton magnetic resonance spectroscopic imaging (1H‐MRSI), termed (2 + 1)D‐CAIPIRINHA, with two standard PI methods: 2D‐GRAPPA and 2D‐CAIPIRINHA at 7 Tesla (T). Methods (2 + 1)D‐CAIPIRINHA is a combination of 2D‐CAIPIRINHA and slice‐CAIPIRINHA. Eight healthy volunteers were measured on a 7T MR scanner using a 32‐channel head coil. The best undersampling patterns were estimated for all three PI methods. The artifact powers, g‐factors, Cramér–Rao lower bounds (CRLB), and root mean square errors (RMSE) were compared quantitatively among the three PI methods. Metabolic maps and spectra were compared qualitatively. Results (2 + 1)D‐CAIPIRINHA allows acceleration in three spatial dimensions in contrast to 2D‐GRAPPA and 2D‐CAIPIRINHA. Thus, this sequence significantly decreased the RMSE of the metabolic maps by 12.1 and 6.9%, on average, for 4