Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma

The aim of the present study was to determine whether there are any clinicopathological or prognostic differences between patients with α-fetoprotein-secreting gastric carcinoma (AFP-SGC) and non-AFP-SGC. Pathological parameters, clinical parameters, and treatment efficacy were compared in patients...

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Veröffentlicht in:	Molecular and clinical oncology 2017-08, Vol.7 (2), p.267-274
Hauptverfasser:	Bozkaya, Yakup, Demirci, Nebi Serkan, Kurtipek, Alican, Erdem, Gökmen Umut, Ozdemir, Nuriye Yildirim, Zengin, Nurullah
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alpha fetoproteins Antigens Care and treatment Chemotherapy Confidence intervals Development and progression Disease Gastric cancer Gene expression Genetic aspects Health aspects Hospitals Laboratories Liver cancer liver metastasis Lymphatic system Medical prognosis Metastasis Multivariate analysis Oncology Performance evaluation Radiation therapy Statistical analysis Stomach cancer Surgery Survival analysis Tumors α-fetoprotein α-fetoprotein-secreting gastric carcinoma
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Zusammenfassung:	The aim of the present study was to determine whether there are any clinicopathological or prognostic differences between patients with α-fetoprotein-secreting gastric carcinoma (AFP-SGC) and non-AFP-SGC. Pathological parameters, clinical parameters, and treatment efficacy were compared in patients with AFP-SGC and non-AFP-SGC. In total, 362 patients (53 with AFP-SGC and 309 with non-AFP-SGC) were included in the present study. Patients with AFP-SGC had significantly higher levels of lymphovascular invasion, perineural invasion (PNI), rate of liver metastasis, and stage IV cancer compared with patients with non-AFP-SGC (P
ISSN:	2049-9450 2049-9469
DOI:	10.3892/mco.2017.1288