Assessment of faecal microbial transfer in irritable bowel syndrome with severe bloating

Of note, however, placebo response rates in similar IBS patient cohorts are reported to be approximately 37.5%, which is considerably lower than the response rate of 75% that we report here. 8 Nonetheless, double-blind, placebo-controlled trials, addressing also microbial changes, are necessary to provide clear answers about the applicability of FMT in IBS and are currently on-going both in our centre ( NCT02299973 ) and elsewhere ( NCT02092402 ; NCT02154867 ). Donor species richness determines faecal microbiota transplantation success in inflammatory bowel disease. J Crohn Colitis 2016; 10: 387-94. doi:10.1093/ecco-jcc/jjv203 8 Shah E, Pimentel M. Placebo effect in clinical trial design for irritable bowel syndrome.