ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways

There is increasing evidence that circular RNA (circRNA) are involved in cancer development, but the regulation and function of human circRNA remain largely unknown. In this study, we demonstrated that ZKSCAN1, a zinc finger family gene, is expressed in both linear and circular (circZKSCAN1) forms o...

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Veröffentlicht in:	Molecular oncology 2017-04, Vol.11 (4), p.422-437
Hauptverfasser:	Yao, Zhicheng, Luo, Jingyan, Hu, Kunpeng, Lin, Jizong, Huang, He, Wang, Qiangliang, Zhang, Peng, Xiong, Zhiyong, He, Chonghua, Huang, Zejian, Liu, Bo, Yang, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics circular RNA Demography Down-Regulation - genetics Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Genetic research Growth HCC Hepatoma Humans Liver Neoplasms - genetics Liver Neoplasms - pathology Male Mice, Nude Middle Aged Neoplasm Invasiveness Physiological aspects qRT‐PCR Reproducibility of Results RNA RNA - genetics RNA - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA‐seq ROC Curve Sequence Analysis, RNA Signal Transduction - genetics Transcription Factors - genetics Transcription Factors - metabolism ZKSCAN1
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Zusammenfassung:	There is increasing evidence that circular RNA (circRNA) are involved in cancer development, but the regulation and function of human circRNA remain largely unknown. In this study, we demonstrated that ZKSCAN1, a zinc finger family gene, is expressed in both linear and circular (circZKSCAN1) forms of RNA in human hepatocellular carcinoma (HCC) tissues and cell lines. Here, we analyzed a cohort of 102 patients and found that expression of both ZKSCAN1mRNA and circZKSCAN1 was significantly lower (P
ISSN:	1574-7891 1878-0261
DOI:	10.1002/1878-0261.12045