Saccharomyces cerevisiae -derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease

Highlights • Parvovirus B19 infection can be life threatening in patients with SCD. • A B19 parvovirus VLP vaccine candidate is in pre-clinical development. • Vaccinated SCD mice responded with binding and neutralizing antibodies. • Mice with SCD responded well to a respiratory virus challenge. • Ra...

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Veröffentlicht in:	Vaccine 2017-06, Vol.35 (29), p.3615-3620
Hauptverfasser:	Penkert, Rhiannon R, Young, Neal S, Surman, Sherri L, Sealy, Robert E, Rosch, Jason, Dormitzer, Philip R, Settembre, Ethan C, Chandramouli, Sumana, Wong, Susan, Hankins, Jane S, Hurwitz, Julia L
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Adjuvants, Immunologic - administration & dosage Allergy and Immunology Anemia Anemia, Sickle Cell - complications animal models Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Bacterial infections Binding Blood Clinical trials Disease Models, Animal Erythema Infectiosum - prevention & control Fungi Genomes heterozygosity Immune response Immune system Immunogenicity Infections Intramuscular Lungs Mice Mucosa Mucosal antibody response Murine respirovirus Neutralizing neutralizing antibodies Parvovirus B19 vaccine Parvovirus B19, Human - genetics Parvovirus B19, Human - immunology Parvoviruses Pathogens patients Polysorbates - administration & dosage Protoparvovirus respiratory system Respiratory tract Respiratory tract diseases Respirovirus Infections - prevention & control Rodents Saccharomyces Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics sickle cell anemia Sickle cell disease Squalene - administration & dosage Systemic antibody Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - isolation & purification Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - genetics Vaccines, Virus-Like Particle - immunology Vaccines, Virus-Like Particle - isolation & purification virus-like particle vaccines Viruses Yeast-derived
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Beschreibung
Zusammenfassung:	Highlights • Parvovirus B19 infection can be life threatening in patients with SCD. • A B19 parvovirus VLP vaccine candidate is in pre-clinical development. • Vaccinated SCD mice responded with binding and neutralizing antibodies. • Mice with SCD responded well to a respiratory virus challenge. • Rapid clinical development of the B19 VLP vaccine for people with SCD is encouraged.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.05.022