Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)

The vast majority of children with sickle cell anemia (SCA) live in Africa, where evidence‐based guidelines for primary stroke prevention are lacking. In Kano, Nigeria, we conducted a feasibility trial to determine the acceptability of hydroxyurea therapy for primary stroke prevention in children wi...

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Veröffentlicht in:	American journal of hematology 2017-08, Vol.92 (8), p.780-788
Hauptverfasser:	Galadanci, Najibah A., Umar Abdullahi, Shehu, Vance, Leah D., Musa Tabari, Abdulkadir, Ali, Shehi, Belonwu, Raymond, Salihu, Auwal, Amal Galadanci, Aisha, Wudil Jibir, Binta, Bello‐Manga, Halima, Neville, Kathleen, Kirkham, Fenella J., Shyr, Yu, Phillips, Sharon, Covert, Brittany V., Kassim, Adetola A., Jordan, Lori C., Aliyu, Muktar H., DeBaun, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Anemia, Sickle Cell - complications Anemia, Sickle Cell - drug therapy Anemia, Sickle Cell - epidemiology Antisickling Agents - administration & dosage Antisickling Agents - adverse effects Antisickling Agents - therapeutic use Child Child, Preschool Children Female Follow-Up Studies Hematology Hospitalization Humans Hydroxyurea Hydroxyurea - administration & dosage Hydroxyurea - adverse effects Hydroxyurea - therapeutic use Incidence Male Medication Adherence Nigeria Prevention Reproducibility of Results Sensitivity and Specificity Sickle cell anemia Sickle cell disease Stroke Stroke - diagnosis Stroke - epidemiology Stroke - etiology Stroke - prevention & control Treatment Outcome Ultrasonography, Doppler, Transcranial Ultrasound
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