Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)

Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)

The vast majority of children with sickle cell anemia (SCA) live in Africa, where evidence‐based guidelines for primary stroke prevention are lacking. In Kano, Nigeria, we conducted a feasibility trial to determine the acceptability of hydroxyurea therapy for primary stroke prevention in children wi...

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Veröffentlicht in:American journal of hematology 2017-08, Vol.92 (8), p.780-788
Hauptverfasser: Galadanci, Najibah A., Umar Abdullahi, Shehu, Vance, Leah D., Musa Tabari, Abdulkadir, Ali, Shehi, Belonwu, Raymond, Salihu, Auwal, Amal Galadanci, Aisha, Wudil Jibir, Binta, Bello‐Manga, Halima, Neville, Kathleen, Kirkham, Fenella J., Shyr, Yu, Phillips, Sharon, Covert, Brittany V., Kassim, Adetola A., Jordan, Lori C., Aliyu, Muktar H., DeBaun, Michael R.
Format: Artikel
Sprache:eng
Schlagworte:
Anemia
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - drug therapy
Anemia, Sickle Cell - epidemiology
Antisickling Agents - administration & dosage
Antisickling Agents - adverse effects
Antisickling Agents - therapeutic use
Child
Child, Preschool
Children
Female
Follow-Up Studies
Hematology
Hospitalization
Humans
Hydroxyurea
Hydroxyurea - administration & dosage
Hydroxyurea - adverse effects
Hydroxyurea - therapeutic use
Incidence
Male
Medication Adherence
Nigeria
Prevention
Reproducibility of Results
Sensitivity and Specificity
Sickle cell anemia
Sickle cell disease
Stroke
Stroke - diagnosis
Stroke - epidemiology
Stroke - etiology
Stroke - prevention & control
Treatment Outcome
Ultrasonography, Doppler, Transcranial
Ultrasound
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Zusammenfassung:The vast majority of children with sickle cell anemia (SCA) live in Africa, where evidence‐based guidelines for primary stroke prevention are lacking. In Kano, Nigeria, we conducted a feasibility trial to determine the acceptability of hydroxyurea therapy for primary stroke prevention in children with abnormal transcranial Doppler (TCD) measurements. Children with SCA and abnormal non‐imaging TCD measurements (≥200 cm/s) received moderate fixed‐dose hydroxyurea therapy (∼20 mg/kg/day). A comparison group of children with TCD measurements 
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.24770