White Matter Integrity on DTI and the Pathologic Staging of Alzheimer’s Disease

Abstract Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer’s disease (AD) patients (n=46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV...

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Veröffentlicht in:	Neurobiology of aging 2017-08, Vol.56, p.172-179
Hauptverfasser:	Kantarci, Kejal, MD, MS, Murray, Melissa E., PhD, Schwarz, Christopher G., PhD, Reid, Robert, PhD, Przybelski, Scott A, Lesnick, Timothy, MS, Zuk, Samantha M, Raman, Mekala R., PhD, Senjem, Matthew L., MS, Gunter, Jeffrey L., PhD, Boeve, Bradley F., MD, Knopman, David S., MD, Parisi, Joseph E., MD, Petersen, Ronald C., MD, PhD, Jack, Clifford R., MD, Dickson, Dennis, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - pathology Alzheimer Disease - diagnostic imaging Alzheimer Disease - pathology Alzheimer's disease Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging DTI Female Humans Internal Medicine Limbic tracts Male Middle Aged Neurology Pathology Severity of Illness Index White matter White Matter - diagnostic imaging White Matter - pathology
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Zusammenfassung:	Abstract Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer’s disease (AD) patients (n=46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV-VI) had significantly elevated mean diffusivity (MD) in the crus of fornix and ventral cingulum tracts, precuneus, and entorhinal white matter on voxel-based analysis after adjusting for age and time from MRI to death (p
ISSN:	0197-4580 1558-1497
DOI:	10.1016/j.neurobiolaging.2017.04.024