Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways

Recent studies have furthered our understanding of the function of long noncoding RNAs (lncRNAs) in numerous biological processes, including cancer. This study investigated the expression of a novel lncRNA, colorectal neoplasia differentially expressed ( CRNDE ), in colorectal carcinoma (CRC) tissue...

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Veröffentlicht in:	Cell death & disease 2017-06, Vol.8 (6), p.e2862-e2862
Hauptverfasser:	Jiang, Huijuan, Wang, Yiqing, Ai, Meiling, Wang, Haowei, Duan, Zhijiao, Wang, Huanan, Zhao, Li, Yu, Jiang, Ding, Yanqing, Wang, Shuang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 38/1 631/337/384/2568 631/80/86 692/699/67/1504/1885 692/699/67/322 82/51 82/80 Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell growth Cell Line, Tumor Cell Movement Cell Proliferation Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cytoplasm Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene expression Heterogeneous-Nuclear Ribonucleoproteins - genetics Heterogeneous-Nuclear Ribonucleoproteins - metabolism Humans Immunology Kinases Life Sciences Male MAP kinase MAP Kinase Signaling System Metastases Mice Mice, Inbred BALB C Mice, Nude Original original-article Polymerase chain reaction Protein kinase Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Ras protein Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Signal transduction
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Zusammenfassung:	Recent studies have furthered our understanding of the function of long noncoding RNAs (lncRNAs) in numerous biological processes, including cancer. This study investigated the expression of a novel lncRNA, colorectal neoplasia differentially expressed ( CRNDE ), in colorectal carcinoma (CRC) tissues and cells by real-time RT-PCR and in situ hybridization, and its biological function using a series of in vitro and in vivo experiments to determine its potential as a prognostic marker and therapeutic target. CRNDE was found to be upregulated in primary CRC tissues and cells ( P
ISSN:	2041-4889 2041-4889
DOI:	10.1038/cddis.2017.258