The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions

The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions

Mg2+ is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca2+ channels and K+ channels and on Ca2+-binding proteins. In general, Mg2+ is considered as the ma...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-8
Hauptverfasser: Kaplan, Peter, Tatarkova, Zuzana, Klacanova, Katarina, Pilchova, Ivana, Racay, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cytochrome
Dehydrogenases
Enzymes
Homeostasis
Kinases
Metabolism
Mitochondria
Oxidation
Permeability
Phosphorylation
Physiology
Proteins
Regulation
Review
Studies
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Zusammenfassung:Mg2+ is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca2+ channels and K+ channels and on Ca2+-binding proteins. In general, Mg2+ is considered as the main intracellular antagonist of Ca2+, which is an essential secondary messenger initiating or regulating a great number of cellular functions. This review examines the effects of Mg2+ on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca2+ handling, and apoptosis.
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/6797460