High pre‐exposure prophylaxis uptake and early adherence among men who have sex with men and transgender women at risk for HIV Infection: the PrEP Brasil demonstration project

Introduction: The efficacy of pre‐exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle‐income settings with concentrated epidemics among men who have sex with men...

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Veröffentlicht in:	Journal of the International AIDS Society 2017, Vol.20 (1), p.21472-n/a
Hauptverfasser:	Hoagland, Brenda, Moreira, Ronaldo I., De Boni, Raquel B., Kallas, Esper G., Madruga, José Valdez, Vasconcelos, Ricardo, Goulart, Silvia, Torres, Thiago S., Marins, Luana M. S., Anderson, Peter L., Luz, Paula M, Costa Leite, Iuri da, Liu, Albert Y., Veloso, Valdilea G., Grinsztejn, Beatriz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Adult AIDS Alcohol use Analysis Anti-HIV Agents - therapeutic use Brazil Clinical medicine Clinical practice guidelines Cohort analysis Data collection Disease prevention Drug dosages DRUG Levels Emtricitabine - therapeutic use Female Funding Health aspects Health risks Hepatitis Heterosexuality HIV HIV infections HIV Infections - drug therapy HIV Infections - prevention & control HIV prevention Homosexuality, Male Human immunodeficiency virus Humans Infections Internet Laboratories Longitudinal Studies Male Medication Adherence MSM MSM (Men who have sex with men) Patient compliance Pediatrics Population Pre-Exposure Prophylaxis PrEP adherence PrEP uptake Prevention Prophylaxis Prospective Studies Public health Regression analysis Risk factors Sexual Behavior Sexually transmitted diseases STD Studies Systematic review Tenofovir - therapeutic use Transgender people Transgender Persons transgender women Urine Womens health Young Adult
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Zusammenfassung:	Introduction: The efficacy of pre‐exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle‐income settings with concentrated epidemics among men who have sex with men (MSM) and transgender women (TGW). Methods: PrEP Brasil is a prospective, multicentre, open‐label demonstration project assessing PrEP delivery in the context of the Brazilian Public Health System. HIV‐uninfected MSM and TGW in 3 referral centres in Rio de Janeiro and São Paulo were evaluated for eligibility and offered 48 weeks of daily emtricitabine/tenofovir for PrEP. Concentrations of tenofovir diphosphate in dried blood spot samples (DBS) at week 4 after enrolment (early adherence) were measured. Predictors of drug levels were assessed using ordinal logistic regression models considering the DBS drug level as a 3 level variable (
ISSN:	1758-2652 1758-2652
DOI:	10.7448/IAS.20.1.21472