Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor

The discovery and characterization of two classes of kappa opioid receptor agonists that are biased for G protein over βarrestin signaling are described.

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Veröffentlicht in:ACS medicinal chemistry letters 2017-07, Vol.8 (7), p.694-700
Hauptverfasser: Bohn, Laura M, Aubé, Jeffrey
Format: Artikel
Sprache:eng
Schlagworte:
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Zusammenfassung:The discovery and characterization of two classes of kappa opioid receptor agonists that are biased for G protein over βarrestin signaling are described.
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.7b00224