Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats

[Purpose] The purpose of this study was to determine whether collagen fibers cause a difference in a contracture resulting from a combination of joint fixation and hindlimb unloading as compared to joint fixation only. [Subjects and Methods] The subjects of this study were 21 female Wistar rats divi...

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Veröffentlicht in:Journal of Physical Therapy Science 2017, Vol.29(7), pp.1192-1195
Hauptverfasser: Matsumoto, Tomohiro, Ono, Takeya, Ishikura, Hideki, Aihara, Kazuki, Sato, Yuta, Tasaka, Atsushi, Umei, Namiko, Tsumiyama, Wakako, Oki, Sadaaki
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Sprache:eng
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Zusammenfassung:[Purpose] The purpose of this study was to determine whether collagen fibers cause a difference in a contracture resulting from a combination of joint fixation and hindlimb unloading as compared to joint fixation only. [Subjects and Methods] The subjects of this study were 21 female Wistar rats divided into 4 groups as follows: Control Group (CON, n=7); Joint Fixation Group (JF, n=7), Hindlimb Unloading Group (HU, n=7), Joint Fixation Plus Hindlimb Unloading Group (JF+HU, n=7). This study was conducted for 1-week. Ankle joint range of motion and positive areas of collagen using fluorescent stain were analyzed. [Results] Ankle joint range of motion in JF + HU showed an increase compared to that of JF. Positive areas of Type I collagen in JF+HU showed an increase as compared with that of JF. [Conclusion] The results of this study suggested that the difference in a contracture caused by only joint immobilization and by a combination of joint immobilization and hindlimb unloading were significantly associated with Type I collagen.
ISSN:0915-5287
2187-5626
DOI:10.1589/jpts.29.1192