Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain

Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain

Highlights • NHERF-1 & -2 are novel interacting partners of mGluR2 and mGluR3. • NHERF-1 & -2 bind to conserved C-terminal motifs on mGluR2/3. • Removal of the PDZ-binding motif enhances mGluR2 signaling. • Subcellular localization of mGluR2/3 is altered in NHERF-2 knockout mice.

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Veröffentlicht in:Neuroscience 2017-06, Vol.353, p.58-75
Hauptverfasser: Ritter-Makinson, Stefanie L, Paquet, Maryse, Bogenpohl, James W, Rodin, Rachel E, Chris Yun, C, Weinman, Edward J, Smith, Yoland, Hall, Randy A
Format: Artikel
Sprache:eng
Schlagworte:
astrocyte
axon
electron microscopy
knockout mice
Neurology
pre-synaptic
protein–protein interaction
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Zusammenfassung:Highlights • NHERF-1 & -2 are novel interacting partners of mGluR2 and mGluR3. • NHERF-1 & -2 bind to conserved C-terminal motifs on mGluR2/3. • Removal of the PDZ-binding motif enhances mGluR2 signaling. • Subcellular localization of mGluR2/3 is altered in NHERF-2 knockout mice.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.03.060