Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models

Highlights • The nitroxide radical TEMPOL given orally limits clinical disease in models of MS. • TEMPOL reduced inflammatory infiltrates and preserved neurofilaments. • TEMPOL lowered costimulatory molecule expression and enriched suppressor cells. • Immunomodulation and therapeutic efficacy combin...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-05, Vol.62, p.332-343
Hauptverfasser:	Neil, Sarah, Huh, Jaebong, Baronas, Victoria, Li, Xinhui, McFarland, Henry F, Cherukuri, Murali, Mitchell, James B, Quandt, Jacqueline A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology EAE Inflammation Multiple sclerosis Neurodegeneration Nitroxide Psychiatry
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container_title	Brain, behavior, and immunity
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creator	Neil, Sarah Huh, Jaebong Baronas, Victoria Li, Xinhui McFarland, Henry F Cherukuri, Murali Mitchell, James B Quandt, Jacqueline A
description	Highlights • The nitroxide radical TEMPOL given orally limits clinical disease in models of MS. • TEMPOL reduced inflammatory infiltrates and preserved neurofilaments. • TEMPOL lowered costimulatory molecule expression and enriched suppressor cells. • Immunomodulation and therapeutic efficacy combine as a promising oral MS therapy.
doi_str_mv	10.1016/j.bbi.2017.02.018
format	Article
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subjects	Allergy and Immunology EAE Inflammation Multiple sclerosis Neurodegeneration Nitroxide Psychiatry
title	Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models
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