Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models

Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models

Highlights • The nitroxide radical TEMPOL given orally limits clinical disease in models of MS. • TEMPOL reduced inflammatory infiltrates and preserved neurofilaments. • TEMPOL lowered costimulatory molecule expression and enriched suppressor cells. • Immunomodulation and therapeutic efficacy combin...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2017-05, Vol.62, p.332-343
Hauptverfasser: Neil, Sarah, Huh, Jaebong, Baronas, Victoria, Li, Xinhui, McFarland, Henry F, Cherukuri, Murali, Mitchell, James B, Quandt, Jacqueline A
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
EAE
Inflammation
Multiple sclerosis
Neurodegeneration
Nitroxide
Psychiatry
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Zusammenfassung:Highlights • The nitroxide radical TEMPOL given orally limits clinical disease in models of MS. • TEMPOL reduced inflammatory infiltrates and preserved neurofilaments. • TEMPOL lowered costimulatory molecule expression and enriched suppressor cells. • Immunomodulation and therapeutic efficacy combine as a promising oral MS therapy.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2017.02.018