Not Your Father's, or Mother's, Rodent: Moving Beyond B6

In this issue of Neuron, Sittig et al. (2016) present research that calls into question the way laboratory mice are used to address questions in basic science and experimental medicine. This research demonstrates strong interactions between mutant alleles and genetic background. In this issue of Neuron, Sittig et al. (2016) present research that calls into question the way laboratory mice are used to address questions in basic science and experimental medicine. This research demonstrates strong interactions with genetic background.