TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate and invertebrate models revealed the TGF-β family to be central regulators of tissue morphogenesis. Members of the TGF-β family direct some of the earliest cell-fate decisions in animal development, coordina...

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Veröffentlicht in:	Cold Spring Harbor perspectives in biology 2017-07, Vol.9 (7), p.a022186
Hauptverfasser:	Mullen, Alan C, Wrana, Jeffrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - metabolism Animals Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - physiology Cell Differentiation Cell Self Renewal Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene Expression Regulation, Developmental Humans Mice PERSPECTIVES Signal Transduction Transforming Growth Factor beta - metabolism
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Beschreibung
Zusammenfassung:	Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate and invertebrate models revealed the TGF-β family to be central regulators of tissue morphogenesis. Members of the TGF-β family direct some of the earliest cell-fate decisions in animal development, coordinate complex organogenesis, and contribute to tissue homeostasis in the adult. Here, we focus on the role of the TGF-β family in mammalian stem-cell biology and discuss its wide and varied activities both in the regulation of pluripotency and in cell-fate commitment.
ISSN:	1943-0264 1943-0264
DOI:	10.1101/cshperspect.a022186