Di-(2-ethylhexyl) phthalate Induces Apoptosis of GC-2spd Cells via TR4/Bcl-2 Pathway

Highlights • GC-2spd cells were exposed to various DEHP concentrations (0, 50, 100, or 200 μM). • We measure the apoptosis rate of GC-2spd cell. • We detect the activity of SOD and GSH-Px, and the content of MDA of GC-2spd cell. • We examine the mRNA and protein levels of TR4, Bcl-2 and caspase-3 of...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-06, Vol.44, p.18-24
Hauptverfasser:	Zhu, Lishan, Lu, Jinchuang, Tang, Xiao, Fu, Guoqing, Duan, Peng, Quan, Chao, Zhang, Ling, Zhang, Zhibing, Chang, Wei, Shi, Yuqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Bcl-2 Caspase 3 - genetics Caspase 3 - metabolism Cell Line Cell Survival - drug effects Cells apoptosis Di-(2-ethylhexyl) phthalate Diethylhexyl Phthalate - toxicity Emergency Endocrine Disruptors - toxicity GC-2spd cells Glutathione Peroxidase - metabolism Malondialdehyde - metabolism Mice Nuclear Receptor Subfamily 2, Group C, Member 2 - metabolism Plasticizers - toxicity Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Messenger - metabolism Superoxide Dismutase - metabolism Testicular orphan nuclear receptor 4
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Zusammenfassung:	Highlights • GC-2spd cells were exposed to various DEHP concentrations (0, 50, 100, or 200 μM). • We measure the apoptosis rate of GC-2spd cell. • We detect the activity of SOD and GSH-Px, and the content of MDA of GC-2spd cell. • We examine the mRNA and protein levels of TR4, Bcl-2 and caspase-3 of GC-2spd cell. • TR4/Bcl-2 pathway might be involved in DEHP −induced GC-2spd cell apoptosis.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.04.003