NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas
Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant ST147 isolate harboring and from a young man who underwent abdominal surgery in India. wa...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2017-07, Vol.61 (7) |
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| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 61 |
| creator | Rojas, Laura J Hujer, Andrea M Rudin, Susan D Wright, Meredith S Domitrovic, T Nicholas Marshall, Steven H Hujer, Kristine M Richter, Sandra S Cober, Eric Perez, Federico Adams, Mark D van Duin, David Bonomo, Robert A |
| description | Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant
ST147 isolate harboring
and
from a young man who underwent abdominal surgery in India.
was located on an IncFII plasmid of ≈90 kb, whereas
was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS
and a "hot-spot region" in the IncFII plasmid. |
| doi_str_mv | 10.1128/AAC.00454-17 |
| format | Article |
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ST147 isolate harboring
and
from a young man who underwent abdominal surgery in India.
was located on an IncFII plasmid of ≈90 kb, whereas
was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS
and a "hot-spot region" in the IncFII plasmid.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00454-17</identifier><identifier>PMID: 28461314</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; beta-Lactamases ; beta-Lactamases - genetics ; beta-Lactamases - metabolism ; Carbapenems - pharmacology ; Carbapenems - therapeutic use ; Epidemiology and Surveillance ; Humans ; India ; Klebsiella Infections - drug therapy ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae ; Klebsiella pneumoniae - enzymology ; Klebsiella pneumoniae - pathogenicity ; Male ; Microbial Sensitivity Tests ; Plasmids - genetics</subject><ispartof>Antimicrobial agents and chemotherapy, 2017-07, Vol.61 (7)</ispartof><rights>Copyright © 2017 American Society for Microbiology.</rights><rights>Copyright © 2017 American Society for Microbiology. 2017 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a527t-c4b885300a918d31f1d555fd4e2f578ee9cc886fceb5622db0baf4fb44a771663</citedby><cites>FETCH-LOGICAL-a527t-c4b885300a918d31f1d555fd4e2f578ee9cc886fceb5622db0baf4fb44a771663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487671/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487671/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28461314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rojas, Laura J</creatorcontrib><creatorcontrib>Hujer, Andrea M</creatorcontrib><creatorcontrib>Rudin, Susan D</creatorcontrib><creatorcontrib>Wright, Meredith S</creatorcontrib><creatorcontrib>Domitrovic, T Nicholas</creatorcontrib><creatorcontrib>Marshall, Steven H</creatorcontrib><creatorcontrib>Hujer, Kristine M</creatorcontrib><creatorcontrib>Richter, Sandra S</creatorcontrib><creatorcontrib>Cober, Eric</creatorcontrib><creatorcontrib>Perez, Federico</creatorcontrib><creatorcontrib>Adams, Mark D</creatorcontrib><creatorcontrib>van Duin, David</creatorcontrib><creatorcontrib>Bonomo, Robert A</creatorcontrib><title>NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant
ST147 isolate harboring
and
from a young man who underwent abdominal surgery in India.
was located on an IncFII plasmid of ≈90 kb, whereas
was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS
and a "hot-spot region" in the IncFII plasmid.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>beta-Lactamases</subject><subject>beta-Lactamases - genetics</subject><subject>beta-Lactamases - metabolism</subject><subject>Carbapenems - pharmacology</subject><subject>Carbapenems - therapeutic use</subject><subject>Epidemiology and Surveillance</subject><subject>Humans</subject><subject>India</subject><subject>Klebsiella Infections - drug therapy</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - enzymology</subject><subject>Klebsiella pneumoniae - pathogenicity</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Plasmids - genetics</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFLHDEUxkNR6tb21nPJUcFoMpNkMhdhum2tsK0Ht1DoIbzJJG5kJ7NNskL_-6auSj14erz3fnyP730IvWf0lLFKnXXd_JRSLjhhzSs0Y7RVRIpW7qEZpVISrig_QG9SuqWlFy19jQ4qxSWrGZ-hX98_fSMCQxjw1c-OMMXwR5uBLMBkGCHZdIIBX_ub4J03EDJerqKFjOdTyD5sbcLLCV9vymzAPuC8srgbbSxseov2HayTffdQD9GPL5-X869kcXVxOe8WBETVZGJ4r5SoKYWWqaFmjg1CCDdwWznRKGtbY5SSztheyKoaetqD467nHJqGSVkfovOd7mbbj3YwNuQIa72JfoT4R0_g9fNN8Ct9M91pwVUjG1YEjh4E4vS7WMp69MnY9RqCnbZJM9VyUZXfNAU92aEmTilF657OMKr_5aFLHvo-D32PH-9wSGOlb6dtDOUTL7Ef_rfxJPwYVv0XvmGQ6Q</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Rojas, Laura J</creator><creator>Hujer, Andrea M</creator><creator>Rudin, Susan D</creator><creator>Wright, Meredith S</creator><creator>Domitrovic, T Nicholas</creator><creator>Marshall, Steven H</creator><creator>Hujer, Kristine M</creator><creator>Richter, Sandra S</creator><creator>Cober, Eric</creator><creator>Perez, Federico</creator><creator>Adams, Mark D</creator><creator>van Duin, David</creator><creator>Bonomo, Robert A</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170701</creationdate><title>NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas</title><author>Rojas, Laura J ; 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Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant
ST147 isolate harboring
and
from a young man who underwent abdominal surgery in India.
was located on an IncFII plasmid of ≈90 kb, whereas
was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS
and a "hot-spot region" in the IncFII plasmid.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>28461314</pmid><doi>10.1128/AAC.00454-17</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use beta-Lactamases beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenems - pharmacology Carbapenems - therapeutic use Epidemiology and Surveillance Humans India Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - pathogenicity Male Microbial Sensitivity Tests Plasmids - genetics |
| title | NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas |
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