NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas

Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant ST147 isolate harboring and from a young man who underwent abdominal surgery in India. wa...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-07, Vol.61 (7)
Hauptverfasser:	Rojas, Laura J, Hujer, Andrea M, Rudin, Susan D, Wright, Meredith S, Domitrovic, T Nicholas, Marshall, Steven H, Hujer, Kristine M, Richter, Sandra S, Cober, Eric, Perez, Federico, Adams, Mark D, van Duin, David, Bonomo, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use beta-Lactamases beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenems - pharmacology Carbapenems - therapeutic use Epidemiology and Surveillance Humans India Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - pathogenicity Male Microbial Sensitivity Tests Plasmids - genetics
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Zusammenfassung:	Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant ST147 isolate harboring and from a young man who underwent abdominal surgery in India. was located on an IncFII plasmid of ≈90 kb, whereas was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS and a "hot-spot region" in the IncFII plasmid.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.00454-17