Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase

Pompholyx is a form of acute dermatitis localized to the palms and soles, presenting as an itchy eruption with vesicles that can amount to bullae if severe. Konstantopoulou, et al discuss the use of azathiprine, an immunosuppressive drug, as treatment for the condition, focusing on the case of a 55-...

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Veröffentlicht in:	BMJ 2005-02, Vol.330 (7487), p.350-351
Hauptverfasser:	Konstantopoulou, M, Belgi, A, Griffiths, K D, Seale, J R C, Macfarlane, A W
Format:	Artikel
Sprache:	eng
Schlagworte:	Azathioprine - adverse effects Clinical Review Dermatitis Dermatology Drug therapy Eczema, Dyshidrotic - drug therapy Erythrocytes - enzymology Humans Immunosuppressive Agents - adverse effects Male Methyltransferases - deficiency Middle Aged Pancytopenia - chemically induced Pancytopenia - enzymology Side effects
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Beschreibung
Zusammenfassung:	Pompholyx is a form of acute dermatitis localized to the palms and soles, presenting as an itchy eruption with vesicles that can amount to bullae if severe. Konstantopoulou, et al discuss the use of azathiprine, an immunosuppressive drug, as treatment for the condition, focusing on the case of a 55-year-old man who developed azathioprine myelotoxicity.
ISSN:	0959-8138 0959-8146 1468-5833 1756-1833
DOI:	10.1136/bmj.330.7487.350