Neonatal alcohol exposure reduces number of parvalbumin-positive interneurons in the medial prefrontal cortex and impairs passive avoidance acquisition in mice deficits not rescued from exercise

Highlights • PD5, 7 and 9 alcohol exposure impairs passive avoidance acquisition but not retrieval. • Impact of PD5, 7 and 9 alcohol exposure on the mPFC is most profound in the ACC. • PD5, 7 and 9 alcohol exposure has long-term impact on ACC volume but not overall mPFC volume. • PD5, 7 and 9 alcoho...

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Veröffentlicht in:	Neuroscience 2017-06, Vol.352, p.52-63
Hauptverfasser:	Hamilton, G.F, Hernandez, I.J, Krebs, C.P, Bucko, P.J, Rhodes, J.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn anterior cingulate cortex Avoidance Learning - drug effects Body Weight - drug effects Cell Count Central Nervous System Depressants - toxicity Ethanol - toxicity executive function fear fetal alcohol spectrum disorders inhibition Interneurons - drug effects Interneurons - metabolism Learning Disorders - chemically induced Learning Disorders - pathology Learning Disorders - rehabilitation Male Mice Mice, Inbred C57BL Mice, Transgenic Nestin - genetics Nestin - metabolism Neurology Organ Size - drug effects Parvalbumins - metabolism Physical Conditioning, Animal Prefrontal Cortex - drug effects Prefrontal Cortex - pathology Psychomotor Disorders - etiology running
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Zusammenfassung:	Highlights • PD5, 7 and 9 alcohol exposure impairs passive avoidance acquisition but not retrieval. • Impact of PD5, 7 and 9 alcohol exposure on the mPFC is most profound in the ACC. • PD5, 7 and 9 alcohol exposure has long-term impact on ACC volume but not overall mPFC volume. • PD5, 7 and 9 alcohol exposure significantly reduces the number of mPFC PV+ cells, most notably in the ACC.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.03.058