In Vivo Characteristics of Corneal Endothelium/Descemet’s membrane Complex for the Diagnosis of Corneal Graft Rejection

In Vivo Characteristics of Corneal Endothelium/Descemet’s membrane Complex for the Diagnosis of Corneal Graft Rejection

Abstract Purpose To evaluate the utility of Endothelial/Descemet’s membrane complex (En/DM) characteristics in diagnosing corneal graft rejection. Design Diagnostic reliability study. Methods 139 eyes (96 corneal grafts post penetrating keratoplasty or Descemet’s stripping automated endothelial kera...

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Veröffentlicht in:American journal of ophthalmology 2017-03, Vol.178, p.27-37
Hauptverfasser: Abou Shousha, Mohamed, MD, PhD, Yoo, Sonia H., MD, Sayed, Mohamed S., MD, Edelstein, Sean, MD, Council, Matthew, MD, Shah, Ravi S., BS, Abernathy, Joshua, BS, Schmitz, Zachary, BS, Stuart, Patrick, PhD, Bentivegna, Rocio, MD, Fernandez, Maria P., MD, Smith, Christopher, MD, Yin, Xiaotang, MD, Harocopos, George J., MD, Dubovy, Sander R., MD, Feuer, William J., MS, Wang, Jianhua, MD, PhD, Perez, Victor L., MD
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Sprache:eng
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Ophthalmology
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Zusammenfassung:Abstract Purpose To evaluate the utility of Endothelial/Descemet’s membrane complex (En/DM) characteristics in diagnosing corneal graft rejection. Design Diagnostic reliability study. Methods 139 eyes (96 corneal grafts post penetrating keratoplasty or Descemet’s stripping automated endothelial keratoplasty: 40 clear, 23 actively rejecting, 24 rejected and 9 non-immunological failed grafts, along with 43 age-matched control eyes) were imaged using high-definition optical coherence tomography. Images were used to describe En/DM and measure central corneal thickness (CCT) and central En/DM thickness (DMT). En/DM rejection index (DRI) was computed to detect the relative En/DM thickening to the entire cornea. Results In actively rejecting grafts, DMT and DRI were significantly greater than controls and clear grafts (28, 17 and 17 μm and 1.5, 1 and 1, respectively; P
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2017.02.026