Using speckle to measure tissue dispersion in optical coherence tomography

Tissue dispersion could be used as a marker of early disease changes to further improve the diagnostic potential of optical coherence tomography (OCT). However, most methods to measure dispersion, described in the literature, rely on the presence of distinct and strong reflectors and are, therefore,...

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Veröffentlicht in:Biomedical optics express 2017-05, Vol.8 (5), p.2528-2535
Hauptverfasser: Photiou, Christos, Bousi, Evgenia, Zouvani, Ioanna, Pitris, Costas
Format: Artikel
Sprache:eng
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Zusammenfassung:Tissue dispersion could be used as a marker of early disease changes to further improve the diagnostic potential of optical coherence tomography (OCT). However, most methods to measure dispersion, described in the literature, rely on the presence of distinct and strong reflectors and are, therefore, rarely applicable . A novel technique has been developed which estimates the dispersion-induced resolution degradation from the image speckle and, as such, is applicable . This method was verified experimentally and was applied to the classification of a set of normal and cancerous colon OCT images resulting in 96% correct classification.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.8.002528