Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient

Highlights • An oral tongue squamous cell carcinoma cell line was developed from a never-smoker. • The cell line UCSF-OT-1109 was authenticated by STR DNA fingerprint analysis. • UCSF-OT-1109 harbored 60 somatically mutated coding genes. • The genomic landscape was distinct from tobacco- or HPV-rela...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oral oncology 2017-06, Vol.69, p.1-10
Hauptverfasser:	Wang, Steven J, Asthana, Saurabh, van Zante, Annemieke, Heaton, Chase M, Phuchareon, Janyaporn, Stein, Leighton, Higuchi, Saito, Kishimoto, Tomoya, Chiu, Charles Y, Olshen, Adam B, McCormick, Frank, Tetsu, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell line Cell Line, Tumor Culture Media, Serum-Free DNA copy number aberration Female Hematology, Oncology and Palliative Medicine Humans Insertion or deletion Mutation Never-smoker Oral tongue squamous cell carcinoma Otolaryngology Single nucleotide polymorphism SKY analysis Smoking Spectral Karyotyping Sphere-forming assay STR DNA fingerprint analysis Tongue Neoplasms - genetics Tongue Neoplasms - pathology Whole-exome sequencing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • An oral tongue squamous cell carcinoma cell line was developed from a never-smoker. • The cell line UCSF-OT-1109 was authenticated by STR DNA fingerprint analysis. • UCSF-OT-1109 harbored 60 somatically mutated coding genes. • The genomic landscape was distinct from tobacco- or HPV-related oral cancer. • The cell line exhibited distinctive focal amplifications in chromosome 19p.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2017.03.020