SU46. Glucose Tolerance in the Probands of Deficit Schizophrenia and Nondeficit Schizophrenia

Background: There is evidence that diabetes has an increased prevalence in the relatives of people with schizophrenia and that deficit and nondeficit schizophrenia differ with regard to family history of diabetes mellitus. This is an attempt to study the variability of GTT between the deficit and non deficit subjects. We also intend to study whether there is variation in GTT in the first-degree relatives of probands with deficit vs nondeficit schizophrenia. Methods: This was a cross-sectional study, carried out on a sample of 30 drug-free patients each with deficit and nondeficit schizophrenia, the first-degree relatives of deficit schizophrenia and normal controls. The samples were drawn out of purposive sampling method. First-degree relatives of the deficit schizophrenia probands were selected in the descending priority such as twin sibling, eldest of the siblings (eldest brother/sister) followed by siblings lower down the birth order. Normal controls were taken from the community in vicinity of hospital. Tools used were General Health Questionaire-12, The Schedule for the Deficit Schizophrenia, and Positive and Negative Symptom Scale for Schizophrenia. Data regarding the metabolic profile (GTT results, fasting glucose levels, pulse pressure, BMI score) were recorded. Results: Our study found a significant impairment in the blood glucose levels on oral glucose tolerance test in patients with deficit schizophrenia as compared to their first-degree siblings ( P < .05), nondeficit schizophrenia probands ( P < .001), and normal controls ( P < .001). Dysglycemia was found in 40% of the subjects in the deficit cohort with 10% of deficit subjects being diagnosed as type 2 diabetes mellitus. A distinct gradation was observed in the dysglycemia patterns with highest abnormalities in the deficit probands, followed by their first-degree siblings, nondeficit probands, and least in the normal control probands. Conclusion: The patients of deficit schizophrenia have greater risk of developing diabetes mellitus II and they need to be regularly investigated for it.