Regulation of BAZ1A and Nucleosome Positioning in the Nucleus Accumbens in Response to Cocaine

Highlights • BAZ1A is downregulated in the NAc of mice exposed repeatedly to cocaine. • BAZ1A is downregulated in the NAc of cocaine-addicted humans. • Overexpression of BAZ1A in mouse NAc reduces cocaine reward as assessed by CPP. • Overexpression of BAZ1A in mouse NAc increases cocaine-induced loc...

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Veröffentlicht in:	Neuroscience 2017-06, Vol.353, p.1-6
Hauptverfasser:	Sun, HaoSheng, Damez-Werno, Diane M, Scobie, Kimberly N, Shao, Ning-Yi, Dias, Caroline, Rabkin, Jacqui, Wright, Katherine N, Mouzon, Ezekiell, Kabbaj, Mohamed, Neve, Rachael, Turecki, Gustavo, Shen, Li, Nestler, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	addiction Animals chromatin Chromatin Assembly and Disassembly - drug effects chromatin remodeling Chromosomal Proteins, Non-Histone - genetics cocaine Cocaine - administration & dosage Cocaine-Related Disorders - genetics Conditioning, Classical - drug effects epigenetics Humans Male Mice, Inbred C57BL Motor Activity - drug effects Neurology Nucleosomes - drug effects Nucleosomes - metabolism Nucleus Accumbens - metabolism RNA, Messenger - metabolism Transcription Factors - genetics
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Zusammenfassung:	Highlights • BAZ1A is downregulated in the NAc of mice exposed repeatedly to cocaine. • BAZ1A is downregulated in the NAc of cocaine-addicted humans. • Overexpression of BAZ1A in mouse NAc reduces cocaine reward as assessed by CPP. • Overexpression of BAZ1A in mouse NAc increases cocaine-induced locomotor activation. • Genome-wide nucleosome occupancy and shift changes after repeated cocaine exposure.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.04.007