Type IV Pilin, PilA, Contributes to Adherence of Burkholderia pseudomallei and Virulence In Vivo

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murin...

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Veröffentlicht in:	Infection and Immunity 2005-02, Vol.73 (2), p.1260-1264
Hauptverfasser:	Essex-Lopresti, Angela E, Boddey, Justin A, Thomas, Richard, Smith, Martin P, Hartley, M. Gill, Atkins, Timothy, Brown, Nat F, Tsang, Chuk Hai, Peak, Ian R. A, Hill, Jim, Beacham, Ifor R, Titball, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Bacterial Adhesion Bacterial Adhesion - genetics Bacterial Adhesion - physiology Bacteriology Biological and medical sciences Burkholderia pseudomallei Burkholderia pseudomallei - genetics Burkholderia pseudomallei - metabolism Burkholderia pseudomallei - pathogenicity Caenorhabditis elegans Caenorhabditis elegans - metabolism Caenorhabditis elegans - microbiology Cells, Cultured epithelial cells Epithelial Cells - metabolism Epithelial Cells - microbiology fimbriae Fimbriae Proteins Fimbriae Proteins - metabolism Fimbriae, Bacterial Fimbriae, Bacterial - genetics Fimbriae, Bacterial - metabolism Fundamental and applied biological sciences. Psychology genetics genome Humans loci melioidosis metabolism Mice Microbiology Miscellaneous Molecular Pathogenesis mutants Nematoda pathogenicity physiology Time Factors virulence
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Beschreibung
Zusammenfassung:	The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.2.1260-1264.2005