Sequencing of sporadic Attention‐Deficit Hyperactivity Disorder (ADHD) identifies novel and potentially pathogenic de novo variants and excludes overlap with genes associated with autism spectrum disorder

Attention‐Deficit Hyperactivity Disorder (ADHD) has high heritability; however, studies of common variation account for

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2017-06, Vol.174 (4), p.381-389
Hauptverfasser:	Kim, Daniel Seung, Burt, Amber A., Ranchalis, Jane E., Wilmot, Beth, Smith, Joshua D., Patterson, Karynne E., Coe, Bradley P., Li, Yatong K., Bamshad, Michael J., Nikolas, Molly, Eichler, Evan E., Swanson, James M., Nigg, Joel T., Nickerson, Deborah A., Jarvik, Gail P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - pathology Attention deficit hyperactivity disorder attention deficit hyperactivity disorder (ADHD) Autism autism spectrum disorder (ASD) Autism Spectrum Disorder - genetics Autism Spectrum Disorder - pathology Biomarkers - analysis Child Exome - genetics exome sequencing Female Genetic Predisposition to Disease Genetics Heritability High-Throughput Nucleotide Sequencing - methods Humans Hyperactivity intellectual disability (ID) Male molecular inversion probe (MIP) sequencing Mutation, Missense Pathogenesis Phenotype sporadic ADHD Transient receptor potential proteins
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Beschreibung
Zusammenfassung:	Attention‐Deficit Hyperactivity Disorder (ADHD) has high heritability; however, studies of common variation account for
ISSN:	1552-4841 1552-485X
DOI:	10.1002/ajmg.b.32527