Reassessment of alkaline phosphatase as serum tumor marker with high specificity in osteosarcoma

The goal of this study was to reassess serum alkaline phosphatase (ALP) as tumor marker in osteosarcoma. We retrospectively examined serum ALP levels at diagnosis, every therapeutic step (neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy), metastasis, and follow‐up and analyzed the role o...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2017-06, Vol.6 (6), p.1311-1322
Hauptverfasser:	Kim, Seung Hyun, Shin, Kyoo‐Ho, Moon, Seong‐Hwan, Jang, Jinyoung, Kim, Hyo Song, Suh, Jin‐Suck, Yang, Woo‐Ick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alkaline Phosphatase Alkaline Phosphatase - blood Biomarkers, Tumor - blood Bone cancer Bone lesions Bone Neoplasms - blood Bone Neoplasms - diagnosis Bone Neoplasms - pathology Bone tumors Cancer Biology Chemotherapy Diagnosis Disease-Free Survival Female High specificity Humans Kaplan-Meier Estimate Male Metastases Metastasis Multivariate analysis Original Research Osteosarcoma Osteosarcoma - blood Osteosarcoma - diagnosis Osteosarcoma - pathology Phosphatase Sarcoma Sensitivity and Specificity Serum Tumor Marker Surgery Survival Tumor Burden Tumor markers
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Zusammenfassung:	The goal of this study was to reassess serum alkaline phosphatase (ALP) as tumor marker in osteosarcoma. We retrospectively examined serum ALP levels at diagnosis, every therapeutic step (neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy), metastasis, and follow‐up and analyzed the role of ALP as tumor marker in 210 osteosarcomas. The diagnostic performances of ALP were validated with pathology‐proven 899 other primary bone lesions. Elevated ALP at diagnosis was associated with inferior overall survival (OS) (Log Rank P
ISSN:	2045-7634 2045-7634
DOI:	10.1002/cam4.1022