Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis

A retrospective, multi-center study of adults with and without chronic rhinosinusitis (CRS) identifies a significant association between rs6967330 in the viral receptor CDHR3 – known to be associated with wheezing and asthma in children – and the development of CRS.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of allergy and clinical immunology 2017-06, Vol.139 (6), p.1990-1992.e2
Hauptverfasser:	Chang, Eugene H., MD, Willis, Amanda L., MSC, McCrary, Hilary C., MPH, Noutsious, George T., PhD, Le, Christopher H., MD, Chiu, Alexander G., MD, Mansfield, Corrine J., BS, Reed, Danielle R., PhD, Brooks, Steven G., MPH, Adappa, Nithin D., MD, Palmer, James N., MD, Cohen, Noam G., MD PhD, Stern, Debra A., MS, Guerra, Stefano, MD PhD, Martinez, Fernando D., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alleles Allergy and Immunology Asthma Cell adhesion Children Chronic infection Deoxyribonucleic acid DNA Genome-wide association studies Genomes Genotype & phenotype Hispanic people Infections Intercellular adhesion molecule 1 Membrane trafficking Mutation Respiratory tract diseases Rhinitis Rhinosinusitis Sinusitis Viruses Wheezing
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Beschreibung
Zusammenfassung:	A retrospective, multi-center study of adults with and without chronic rhinosinusitis (CRS) identifies a significant association between rs6967330 in the viral receptor CDHR3 – known to be associated with wheezing and asthma in children – and the development of CRS.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2016.10.027