Host–microbiota interactions: epigenomic regulation

Host–microbiota interactions: epigenomic regulation

Highlights • Epigenomic modifications regulate transcription in response to environmental cues. • Epigenomic regulation of intestinal homeostasis can be altered by the microbiota. • Microbiota-derived short chain fatty acids inhibit histone deacetylases. • Epigenomics represents a developing link be...

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Veröffentlicht in:Current opinion in immunology 2017-02, Vol.44, p.52-60
Hauptverfasser: Woo, Vivienne, Alenghat, Theresa
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Bacteria
Epigenesis, Genetic
Epigenomics
Fatty Acids, Volatile - metabolism
Histone Deacetylases - metabolism
Host-Pathogen Interactions
Humans
Microbiota - immunology
Symbiosis
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Zusammenfassung:Highlights • Epigenomic modifications regulate transcription in response to environmental cues. • Epigenomic regulation of intestinal homeostasis can be altered by the microbiota. • Microbiota-derived short chain fatty acids inhibit histone deacetylases. • Epigenomics represents a developing link between the microbiota and host cells.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2016.12.001