In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory

In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory

Highlights • Epigenetic regulation represents a key mechanism of learning, memory and cognition. • Chromatin topology is emerging as a major regulator of neuronal gene expression. • Dynamic chromatin topology changes correlate with activity-dependent transcription. • DNA double-strand breaks facilit...

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Veröffentlicht in:Current opinion in neurobiology 2017-04, Vol.43, p.48-55
Hauptverfasser: Watson, L Ashley, Tsai, Li-Huei
Format: Artikel
Sprache:eng
Schlagworte:
Chromatin - chemistry
Epigenesis, Genetic
Genome
Histones - genetics
Humans
Learning - physiology
Memory - physiology
Neurology
Psychiatry
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Beschreibung
Zusammenfassung:Highlights • Epigenetic regulation represents a key mechanism of learning, memory and cognition. • Chromatin topology is emerging as a major regulator of neuronal gene expression. • Dynamic chromatin topology changes correlate with activity-dependent transcription. • DNA double-strand breaks facilitate induction of immediate early gene transcription.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2016.12.002