ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF STEM BARK EXTRACT OF BOMBAX CEIBA COLLECTED LOCALLY FROM SOUTH PUNJAB AREA OF PAKISTAN
Background: Ethnic medication systems have been used extensively by humans since their origin. Now a day, in the developing countries these systems are being used due to their effectiveness and affordability. Especially inhabitants of rural areas still rely on these systems as first line of treatmen...
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Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2017, Vol.14 (2), p.9-15 |
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Sprache: | eng |
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Zusammenfassung: | Background: Ethnic medication systems have been used extensively by
humans since their origin. Now a day, in the developing countries these
systems are being used due to their effectiveness and affordability.
Especially inhabitants of rural areas still rely on these systems as
first line of treatment against diseased conditions. Till now, majority
of medicines is derived from the natural origin particularly plants
owing to their little side effects and cost effectiveness. Materials
and Methods: In the present work, we evaluated antibacterial and
antioxidant activity of methanolic extract of Bombax ceiba stem bark.
Total phenolic and flavonoid contents were also assessed in the
extract. The antioxidant capacity was determined by DPPH, Nitric Oxide
scavenging and reducing power activity. For antibacterial activity,
Gram-negative ( Escherichia coli , Pseudomonas aeruginosa and
Salmonella typhi ) and Gram-positive bacteria ( Bacillus subtilis ,
Staphylococcus aureus ) were used. Results: Phenolic content was
133.21±1.56 µg GAE/mg of extract while Flavonoid content was
997.93±2.14 µg QE/mg. Plant extract demonstrated strong
antiradical activity with EC50 18.78 ± 0.69 and 23.62 ±
1.99µg/ml for Nitric Oxide and DPPH assay respectively while EC50
in case of reducing power activity was 139.4 ± 0.98µg/ml.
Plant extract displayed inhibitory effect against microbial growth with
S. typhi as the most resistant strain and Staphylococcus aureus the
most sensitive one. Conclusion: This study revealed that Bombax ceiba
of local origin has broad spectrum antibacterial activity and it can
also provide defense against oxidative stress. |
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ISSN: | 0189-6016 2505-0044 |
DOI: | 10.21010/ajtcam.v14i2.2 |