In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977)

Lascufloxacin exhibited a broad spectrum of activity against various clinical isolates. Furthermore, lascufloxacin showed the most potent activity against Gram-positive bacteria among the quinolones tested and incomplete cross-resistance against existing quinolone-resistant strains. Enzymatic analys...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-06, Vol.61 (6)
Hauptverfasser:	Kishii, Ryuta, Yamaguchi, Yuko, Takei, Masaya
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Drug Resistance, Bacterial Escherichia coli Escherichia coli - drug effects Escherichia coli - isolation & purification Fluoroquinolones Fluoroquinolones - pharmacology Humans Microbial Sensitivity Tests Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - isolation & purification Susceptibility
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Zusammenfassung:	Lascufloxacin exhibited a broad spectrum of activity against various clinical isolates. Furthermore, lascufloxacin showed the most potent activity against Gram-positive bacteria among the quinolones tested and incomplete cross-resistance against existing quinolone-resistant strains. Enzymatic analysis indicated that lascufloxacin had potent inhibitory activity against both wild-type and mutated target enzymes. These results suggest that lascufloxacin may be useful in treating infections caused by various pathogens, including quinolone-resistant strains.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00120-17