Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: A longitudinal in vivo MRI study

Highlights • Maternal immune activation leads to brain structural changes. • Cortical volume decreases between post-natal day 50 and 100 and is static thereafter. • Hippocampus volume decreases early and is maintained into adulthood. • TBM reveals previously unappreciated changes in grey and white m...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-07, Vol.63, p.50-59
Hauptverfasser:	Crum, William R, Sawiak, Stephen J, Chege, Winfred, Cooper, Jonathan D, Williams, Steven C.R, Vernon, Anthony C
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amygdala - pathology Animals Brain - immunology Brain - pathology Cortex Disease Models, Animal Female Hippocampus - pathology Image Processing, Computer-Assisted Longitudinal Studies Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Maternal immune activation Mental Disorders - pathology Poly I-C - pharmacology Poly(I:C) Pregnancy Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - physiopathology Psychiatry Rats Rats, Sprague-Dawley schizophrenia Special Issue on Perinatal Inflammation Volume
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Zusammenfassung:	Highlights • Maternal immune activation leads to brain structural changes. • Cortical volume decreases between post-natal day 50 and 100 and is static thereafter. • Hippocampus volume decreases early and is maintained into adulthood. • TBM reveals previously unappreciated changes in grey and white matter.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.12.008