Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers enhanced survival in human serum

Highlights • Saprophyte Leptospira biflexa expressing LigA or LigB was able to acquire FH and C4BP. • Bound complement regulators retained cofactor activities of FI in the cleavage of C3b and C4b. • Expression of LigA and LigB in saprophyte L. biflexa enhanced their survival in human serum. • MAC de...

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Veröffentlicht in:	Immunology letters 2016-05, Vol.173, p.61-68
Hauptverfasser:	Castiblanco-Valencia, Mónica M, Fraga, Tatiana R, Breda, Leandro C.D, Vasconcellos, Sílvio A, Figueira, Cláudio P, Picardeau, Mathieu, Wunder, Elsio, Ko, Albert I, Barbosa, Angela S, Isaac, Lourdes
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antigens, Bacterial - immunology Antigens, Bacterial - metabolism C4BP Cell Survival Complement Complement C3b - metabolism Complement C4b - metabolism Complement Factor H - metabolism Complement Factor I - metabolism Complement Membrane Attack Complex - immunology Factor H Food Chain Humans Immune Evasion Leptospira Leptospira - pathogenicity Leptospira - physiology Leptospira biflexa Leptospirosis - immunology Lig proteins Protein Binding
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Zusammenfassung:	Highlights • Saprophyte Leptospira biflexa expressing LigA or LigB was able to acquire FH and C4BP. • Bound complement regulators retained cofactor activities of FI in the cleavage of C3b and C4b. • Expression of LigA and LigB in saprophyte L. biflexa enhanced their survival in human serum. • MAC deposition on lig -transformed L. biflexa was intermediate between saprophyte and pathogenic strains. • Lig proteins contribute to control complement activation on the leptospiral surface
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.03.005