Human adipose tissue accumulation is associated with pro-inflammatory changes in subcutaneous rather than visceral adipose tissue

The importance of the involvement of adipose tissue macrophage subpopulations in obesity-related disorders is well known from different animal models, but human data are scarcer. Subcutaneous ( n =44) and visceral ( n =52) adipose tissues of healthy living kidney donors were obtained during living d...

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Veröffentlicht in:	Nutrition & diabetes 2017-04, Vol.7 (4), p.e264-e264
Hauptverfasser:	Lesna, I Kralova, Cejkova, S, Kralova, A, Fronek, J, Petras, M, Sekerkova, A, Thieme, F, Janousek, L, Poledne, R
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 692/499 Adult Body Mass Index Clinical Nutrition Diabetes Epidemiology Female Humans Inflammation - etiology Inflammation - metabolism Internal Medicine Intra-Abdominal Fat - metabolism Macrophages - metabolism Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Obesity - complications Obesity - metabolism Phagocytes - metabolism Short Communication Subcutaneous Fat - metabolism
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Zusammenfassung:	The importance of the involvement of adipose tissue macrophage subpopulations in obesity-related disorders is well known from different animal models, but human data are scarcer. Subcutaneous ( n =44) and visceral ( n =52) adipose tissues of healthy living kidney donors were obtained during living donor nephrectomy. Stromal vascular fractions were isolated and analysed by flow cytometry using CD14, CD16, CD36 and CD163 antibodies. Total macrophage numbers in subcutaneous adipose tissue increased ( P =0.02) with body mass index (BMI), with a similar increase seen in the proportion of phagocytic CD14+CD16+CD36 high macrophages ( P
ISSN:	2044-4052 2044-4052
DOI:	10.1038/nutd.2017.15