Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping

Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping

The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influenc...

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Veröffentlicht in:Genes and immunity 2017-03, Vol.18 (2), p.95-99
Hauptverfasser: Cyr, D D, Allen, A S, Du, G-J, Ruffin, F, Adams, C, Thaden, J T, Maskarinec, S A, Souli, M, Guo, S, Dykxhoorn, D M, Scott, W K, Fowler Jr, V G
Format: Artikel
Sprache:eng
Schlagworte:
631/208/721
African Americans - genetics
Bacteremia
Bacteremia - epidemiology
Bacteremia - genetics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Chromosome 6
Gene Expression
Gene mapping
Genetic diversity
Genetic Predisposition to Disease
Genomes
Histocompatibility antigen HLA
Human Genetics
Humans
Immune response
Immunology
Incidence
Original
original-article
Polymorphism, Single Nucleotide
Single-nucleotide polymorphism
Staphylococcal Infections - epidemiology
Staphylococcal Infections - genetics
Staphylococcus aureus
Statistical analysis
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Zusammenfassung:The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influence susceptibility to SAB in AAs. A total of 565 adult AAs (390 cases with SAB; 175 age-matched controls) were genotyped for AM analysis. A case-only admixture score and a mixed χ 2 (1df) score (MIX) to jointly evaluate both single-nucleotide polymorphism (SNP) and admixture association ( P
ISSN:1466-4879
1476-5470
DOI:10.1038/gene.2017.6