Human Immunodeficiency Virus Type 1 DNA Decay Dynamics With Early, Long-term Virologic Control of Perinatal Infection

Background. Early antiretroviral therapy (ART) limits proviral reservoirs, a goal for human immunodeficiency virus type 1 (HIV-1) remission strategies. Whether this is an immediate or long-term effect of virologic suppression (VS) in perinatal infection is unknown. Methods. We quantified HIV-1 DNA l...

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Veröffentlicht in:	Clinical infectious diseases 2017-06, Vol.64 (11), p.1471-1478
Hauptverfasser:	Uprety, Priyanka, Patel, Kunjal, Karalius, Brad, Ziemniak, Carrie, Chen, Ya Hui, Brummel, Sean S., Siminski, Suzanne, Van Dyke, Russell B., Seage, George R., Persaud, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Age Age factors AIDS Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active ARTICLES AND COMMENTARIES CD4 antigen CD4 Lymphocyte Count Cells Child, Preschool Cohort Studies Decay Deoxyribonucleic acid DNA DNA, Viral - blood DNA, Viral - metabolism Dynamics Editor's Choice Estimates Female Follow-Up Studies Half-life HIV HIV Infections - drug therapy HIV Infections - prevention & control HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus Humans Infant Infant, Newborn Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - virology Linear Models Longitudinal Studies Low concentrations Major Male Perinatal infection Peripheral blood mononuclear cells Proviruses - genetics Regression Regression analysis Remission Therapy Trajectories Trajectory analysis Viral Load - drug effects Viruses
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Zusammenfassung:	Background. Early antiretroviral therapy (ART) limits proviral reservoirs, a goal for human immunodeficiency virus type 1 (HIV-1) remission strategies. Whether this is an immediate or long-term effect of virologic suppression (VS) in perinatal infection is unknown. Methods. We quantified HIV-1 DNA longitudinally for up to 14 years in peripheral blood mononuclear cells (PBMCs) among 61 perinatally HIV-1–infected youths in the Pediatric HIV/AIDS Cohort Study who achieved VS at different ages. Participants in group 1 (n = 13) were
ISSN:	1058-4838 1537-6591 1537-6591
DOI:	10.1093/cid/cix192