Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma

Highlights • We calculated gene fusion rates in patients with mucoepidermoid carcinoma. • This is among the largest mucoepidermoid carcinoma cohorts to date. • Fusion status did not significantly associate with tumor grade or survival. • In previous studies, fusion status prognosis was likely confou...

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Veröffentlicht in:	Oral oncology 2017-05, Vol.68, p.5-8
Hauptverfasser:	Birkeland, Andrew C, Foltin, Susan K, Michmerhuizen, Nicole L, Hoesli, Rebecca C, Rosko, Andrew J, Byrd, Serena, Yanik, Megan, Nor, Jacques E, Bradford, Carol R, Prince, Mark E, Carey, Thomas E, McHugh, Jonathan B, Spector, Matthew E, Brenner, J. Chad
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Mucoepidermoid - genetics Carcinoma, Mucoepidermoid - pathology Cohort Studies CRTC1-MAML2 CRTC1/3-MAML2 CRTC3-MAML2 DNA-Binding Proteins - genetics Female Gene Fusion Head and neck cancer Hematology, Oncology and Palliative Medicine Humans Male Mucoepidermoid carcinoma Mutation Nuclear Proteins - genetics Otolaryngology Retrospective Studies Survival Analysis Transcription Factors - genetics
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Zusammenfassung:	Highlights • We calculated gene fusion rates in patients with mucoepidermoid carcinoma. • This is among the largest mucoepidermoid carcinoma cohorts to date. • Fusion status did not significantly associate with tumor grade or survival. • In previous studies, fusion status prognosis was likely confounded by tumor grade. • Further characterization of additional mutational drivers is needed.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2017.02.025