Prognostic role of B7-H4 in patients with non-small cell lung cancer: A meta-analysis

B7 homolog 4 (B7-H4) has been recently reported to be a prognostic marker in non-small cell lung cancer (NSCLC) in some studies. However, the results remained conflicting. Thus, we aimed to comprehensively assess the association between B7-H4 expression and prognosis of NSCLC patients by performing...

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Veröffentlicht in:	Oncotarget 2017-04, Vol.8 (16), p.27137-27144
Hauptverfasser:	Tan, Zhibo, Shen, Weixi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Gene Expression Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Neoplasm Grading Neoplasm Metastasis Neoplasm Staging Odds Ratio Prognosis Publication Bias Research Paper Survival Analysis V-Set Domain-Containing T-Cell Activation Inhibitor 1 - genetics V-Set Domain-Containing T-Cell Activation Inhibitor 1 - metabolism
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Zusammenfassung:	B7 homolog 4 (B7-H4) has been recently reported to be a prognostic marker in non-small cell lung cancer (NSCLC) in some studies. However, the results remained conflicting. Thus, we aimed to comprehensively assess the association between B7-H4 expression and prognosis of NSCLC patients by performing a meta-analysis. Relevant publications were thoroughly searched of PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were applied to evaluate the effects. A total of 9 studies comprising 1444 patients were included in this meta-analysis. B7-H4 overexpression was associated with presence of lymph node metastasis (OR=3.59, 95%CI=2.39-5.38, p
ISSN:	1949-2553 1949-2553
DOI:	10.18632/oncotarget.15648