Paradoxical aging in HIV: immune senescence of B Cells is most prominent in young age

Combination antiretroviral therapies (cART)can lead to normal life expectancy in HIV-infected persons, and people aged >50 yrs represent the fastest growing HIV group. Although HIV and aging are independently associated with impaired humoral immunity, immune status in people aging with HIV is rel...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2017-04, Vol.9 (4), p.1307-1325
Hauptverfasser:	Rinaldi, Stefano, Pallikkuth, Suresh, George, Varghese K, de Armas, Lesley R, Pahwa, Rajendra, Sanchez, Celeste M, Pallin, Maria Fernanda, Pan, Li, Cotugno, Nicola, Dickinson, Gordon, Rodriguez, Allan, Fischl, Margaret, Alcaide, Maria, Gonzalez, Louis, Palma, Paolo, Pahwa, Savita
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging - immunology Aging - pathology Antibodies, Viral - biosynthesis B-Lymphocytes - immunology Cellular Senescence - immunology Female Hemagglutination Inhibition Tests HIV Infections - immunology HIV Infections - pathology Humans Immunologic Memory Influenza A Virus, H1N1 Subtype - immunology Influenza Vaccines Male Middle Aged Research Paper Vaccination Young Adult
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Zusammenfassung:	Combination antiretroviral therapies (cART)can lead to normal life expectancy in HIV-infected persons, and people aged >50 yrs represent the fastest growing HIV group. Although HIV and aging are independently associated with impaired humoral immunity, immune status in people aging with HIV is relatively unexplored. In this study influenza vaccination was used to probe age associated perturbations in the B cell compartment of HIV-negative "healthy controls" (HC) and virologically controlled HIV-infected participants on cART (HIV) (n=124), grouped by age as young (
ISSN:	1945-4589 1945-4589
DOI:	10.18632/aging.101229