Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis

The core mechanism of Late-onset hypogonadism (LOH) is the deficiency of androgen due to the functional and quantitative decline of testicular Leydig cells. Here we explored the protective effect of calretinin, a Ca -binding protein, on Leydig cells. We found in MLTC-1 cells transfected with LV-calb...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2017-04, Vol.9 (4), p.1269-1279
Hauptverfasser:	Xu, Wendan, Zhu, Qian, Zhang, Bei, Liu, Shan, Dai, Xiaonan, Gao, Chao, Gao, Li, Cui, Yugui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Apoptosis Regulatory Proteins - metabolism Calbindin 2 - genetics Cell Line Cell Proliferation - genetics Hypogonadism - pathology Leydig Cells - pathology Male MAP Kinase Signaling System - genetics Mice Mitochondria - genetics Oncogene Protein v-akt - genetics Research Paper RNA, Small Interfering - genetics S Phase - genetics Testis - pathology
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Zusammenfassung:	The core mechanism of Late-onset hypogonadism (LOH) is the deficiency of androgen due to the functional and quantitative decline of testicular Leydig cells. Here we explored the protective effect of calretinin, a Ca -binding protein, on Leydig cells. We found in MLTC-1 cells transfected with LV-calb2, the cell viability and optical density (OD) were higher (
ISSN:	1945-4589 1945-4589
DOI:	10.18632/aging.101226