Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue

Background Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression...

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Veröffentlicht in:	Obesity surgery 2017-06, Vol.27 (6), p.1514-1523
Hauptverfasser:	Jürets, Alexander, Itariu, Bianca Karla, Keindl, Magdalena, Prager, Gerhard, Langer, Felix, Grablowitz, Viktor, Zeyda, Maximilian, Stulnig, Thomas Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bariatric Surgery Body fat Cachexia - genetics Caspase 3 - metabolism Female Gastrointestinal surgery Gene Expression Humans Lipid Metabolism Male Medicine Medicine & Public Health Metabolism Obesity Obesity, Morbid - metabolism Obesity, Morbid - surgery Original Contributions Subcutaneous Fat - metabolism Surgery Surgical outcomes Tumor Necrosis Factor-alpha - metabolism Up-Regulation
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Zusammenfassung:	Background Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression reflect a restoration of a healthy lean phenotype after bariatric surgery. Methods Thirty-one severely obese patients (BMI ≥ 40 kg/m 2 ) were examined before and after surgery. subcutaneous adipose tissue (SAT) was collected during and 1 year after bariatric surgery. SAT from 20 matched lean and overweight patients (BMI
ISSN:	0960-8923 1708-0428
DOI:	10.1007/s11695-016-2477-5